Genomic research, publics and experts in Latin America: Nation, race and body

The articles in this issue highlight contributions that studies of Latin America can make to wider debates about the effects of genomic science on public ideas about race and nation. We argue that current ideas about the power of genomics to transfigure and transform existing ways of thinking about human diversity are often overstated. If a range of social contexts are examined, the effects are uneven. Our data show that genomic knowledge can unsettle and reinforce ideas of nation and race; it can be both banal and highly politicized. In this introduction, we outline concepts of genetic knowledge in society; theories of genetics, nation and race; approaches to public understandings of science; and the Latin American contexts of transnational ideas of nation and race

Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study

In the era of personalized medical practice, understanding the genetic basis of patient-specific adverse drug reaction (ADR) is a major challenge. Clozapine provides effective treatments for schizophrenia but its usage is limited because of life-threatening agranulocytosis. A recent high impact study showed the necessity of moving clozapine to a first line drug, thus identifying the biomarkers for drug-induced agranulocytosis has become important. Here we report a methodology termed as antithesis chemical-protein interactome (CPI), which utilizes the docking method to mimic the differences in the drug-protein interactions across a panel of human proteins. Using this method, we identified HSPA1A, a known susceptibility gene for CIA, to be the off-target of clozapine. Furthermore, the mRNA expression of HSPA1A-related genes (off-target associated systems) was also found to be differentially expressed in clozapine treated leukemia cell line. Apart from identifying the CIA causal genes we identified several novel candidate genes which could be responsible for agranulocytosis. Proteins related to reactive oxygen clearance system, such as oxidoreductases and glutathione metabolite enzymes, were significantly enriched in the antithesis CPI. This methodology conducted a multi-dimensional analysis of drugs' perturbation to the biological system, investigating both the off-targets and the associated off-systems to explore the molecular basis of an adverse event or the new uses for old drugs

Caso de estudio "concesión aguas"

A través de la aplicación de las herramientas financieras aprendidas durante la especialización (Proyección de Estados Financieros, Flujo de caja libre, tasa de descuento),se llega a valorar la Concesión de Aguas, para ofrecer a los accionistas privados un rango de valor de mercado que les permita vender su participación. Pero el caso no sea queda en los números fríos de las proyecciones ya que ofrece la posibilidad de entender cómo se potencializa el valor de la concesión y cuáles son los factores de éxito que permitieron llevar a feliz término la operación.introducción. Justificación. Entendimiento de las concesiones de aguas en Colombia. Concesión de aguas. Análisis financiero y valoración de una concesión. Etapas del proceso de venta. Bibliografía.Especialista en finanzas corporativas.EspecializaciónPM

Material and environment dependant temperature measurement in continuous annealing furnaces for sheet and black plate

20.00; Translated from German (Stahl Eisen 1986 v. 106(22) p. 90-95)Available from British Library Document Supply Centre- DSC:9022.06(BISI-Trans--26296)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo